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Chemical Name: (2R)-1-{4-[(2R
6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1
CAS Number: 1707289-21-1
LY364947 inhibits in vivo Smad2 phosphorylation within the NMuMg cells with IC50 of 135 nM
and dosing every four days causes 63% tumor growth inhibition (TGI)
Vinorelbine ine hydrobromide Chemical Name: (2R)-1-{4-[(2RVinorelbine is a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with