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K-Ras(G12C) inhibitor 12 839977 0 or aboveK Ras(G12C) inhibitor 12 is a K Ras(G12C) inhibitor, the half maximum effective concentration (EC50) for K Ras(G12C) inhibitor 12 in H1792 cells is 0. 32 M. IC50 value: 0. 32 M (EC50)Target: K RasBinding of K Ras(G12C) inhibitor 12 to K Ras(G12C) disrupts both switch I and switch II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. In the absence of K Ras(G12C) inhibitor 12, K Ras(G12C) shows a slight
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