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It has ~28-fold greater selectivity over UCH-L3 (ubiquitin C-terminal hydrolase L3)
Chin Med J (Engl)
Rogóz Z
Chemical Name: 4-((2-acrylamidophenyl)amino)-N-(2-chloro-6-methylphenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide
CAS Number: 1073160-26-5
SB 415286 Catalog No.:M10079-2 It has ~28-fold greater selectivitySB 415286 is a potent and selective cell permeable, ATP competitive inhibitor of GSK3 with an IC50 value of 78 nM (similar potency for GSK3) and a Ki value of 31 nM. Pharmacological GSK 3 inhibitors are potential drugs for the treatment of neurodegenerative diseases, cancer and diabetes. Product information CAS Number: 264218 23 7 Molecular Weight: 359. 72 Formula: C16H10ClN3O5 Chemical Name: 3 [(3 chloro 4 hydroxyphenyl)amino] 4 (2 nitrophenyl) 2,5
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